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RecruitingMalignant Gastric Outlet Obstruction

Roux-en-Y Gastric Bypass Versus Loop Gastrojejunostomy for Malignant Gastric Outlet Obstruction

Eligible age

18+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

This study is intended to investigate whether roux-en-y bypass surgery is superior to conventional loop gastrojejunostomy for Malignant gastric outlet obstruction in terms of tolerance to solid food intake. We hypothesize that roux-en-y bypass will be associated with improved solid food intake in the first 30 days after surgery.

Sponsor: Corewell Health West

You may qualify if…

  • ✓ 1. Provision of signed and dated informed consent form.
  • ✓ 2. Stated willingness to comply with all study procedures and availability for the duration of the study.
  • ✓ 3. Male or female aged ≥18 years old.
  • ✓ 4. Patients with a diagnosis of malignant gastric outlet obstruction. i. Defined as malignant cancer growth of any organ origin in the area of the distal stomach or duodenum preventing normal gastric emptying as determined by symptoms and cross-sectional imaging studies.
  • ✓ ii. Symptoms can include abdominal distention, abdominal pain, nausea and vomiting.
  • ✓ iii. Cross sectional imaging findings can include tumor growth in the area of the distal stomach or duodenum, gastric distention, fluid filled stomach and decompressed bowel distal to obstruction point.
  • ✓ 5. Patients deemed to benefit from surgical bypass as opposed to stent placement, by the primary surgeon. This includes assessing participants survival chances and ability to undergo a surgical procedure.
  • ✓ 6. Patients in a general health status that permits abdominal surgery under general anesthesia. As determined by primary surgeon and anesthesiologist.

You may not qualify if…

  • ✕ 1. Patients that have had previous treatment for malignant gastric outlet obstruction.
  • ✕ a. Including any previous surgery or stent placement for MGOO
  • ✕ 2. Patients with MGOO deemed to benefit more from endoscopic stent placement rather than surgery for symptom relief. This assessment will be at treating surgeon's discretion.

Where it's recruiting

Michigan

Grand Rapids

Source: ClinicalTrials.gov · NCT05986890 · last updated 2025-06-17