RecruitingAlzheimer Disease
Low-Intensity Focused Ultrasound (LIFU) Neuromodulation
Eligible age
45–85 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This study is a prospective, single-center, single-arm early feasibility study, to establish safety and tolerability of LIFU for neuromodulation in patients with mild cognitive impairment ( MCI) due to Alzheimer's disease.
Sponsor: Ali Rezai
You may qualify if…
- ✓ Males and non-pregnant females, aged 45-85 years
- ✓ Able and willing to give informed consent
- ✓ Must meet the clinical criteria for MCI due to Alzheimer's disease
- ✓ If receiving concurrent treatment with an AChEI and/or memantine, has been on a stable dose for at least 45 days
- ✓ Able to communicate sensations during the LIFU procedure
You may not qualify if…
- ✕ Unable to undergo MR-imaging because of implanted pacemakers, medication pumps, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves or cochlear implants), shrapnel fragments, permanent make-up or small metal fragments in the eye that welders and other metal workers may have, or if candidates are uncomfortable in small spaces (have claustrophobia).
- ✕ Participants with more than 30% of the skull area traversed by the sonication pathway are covered by scars, scalp disorders (e.g., eczema), atrophy of the scalp, or implanted objects in the skull or the brain.
- ✕ Participants with a history of seizure disorder.
- ✕ Participants with clinically significant chronic pulmonary disorders e.g., severe emphysema, pulmonary vasculitis, or other causes of reduced pulmonary vascular cross-sectional area.
- ✕ Participant does not speak English
- ✕ Participant is pregnant or planning to be pregnant
Where it's recruiting
West Virginia
Morgantown
Source: ClinicalTrials.gov · NCT05997030 · last updated 2025-11-24