RecruitingMalignant Peritoneal MesotheliomaPeritoneal MesotheliomaMesothelioma
A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma
Eligible age
18+ yrs
Accepts
All genders
Locations
7 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this study is to find out whether intraperitoneal or intravenous chemotherapy given after cytoreductive surgery and HIPEC are effective treatments for people with malignant peritoneal mesothelioma. Outcomes will be compared by observing intraperitoneal versus intravenous treatments to analyze if one is better than the other.
Sponsor: Memorial Sloan Kettering Cancer Center
You may qualify if…
- ✓ Patient age 18 years or older, both sexes.
- ✓ Clinical diagnosis of MPM at enrolling institution.
- ✓ Prior to randomization, intraoperative pathologic confirmation of epithelioid MPM at enrolling institution.
- ✓ Complete or near-complete CRS achieved.
- ✓ Patient must be planning to undergo complete cytoreduction of all peritoneal disease.
- ✓ ECOG performance status ≤ 1.
- ✓ Hematology: ANC ≥ 1,500/µl.
- ✓ Platelets \> 75,000/µl.
You may not qualify if…
- ✕ Subjects who have previously undergone intraperitoneal chemotherapy or systemic chemotherapy for peritoneal mesothelioma.
- ✕ Subjects who have previously received platinum-containing chemotherapy regimens.
- ✕ Subjects with preoperative or intraoperative biopsy consistent with sarcomatoid mesothelioma, well-differentiated papillary mesothelioma, or benign multicystic mesothelioma.
- ✕ Other prior malignancies, except for cured non-melanoma skin cancer, curatively treated in situ carcinoma of the cervix, adequately treated malignancies for which there has been no evidence of activity for more than three years, or indolent tumors for which observation over two years is a reasonable option.
- ✕ High suspicion for extra-abdominal metastases.
- ✕ Women who are pregnant or lactating.
- ✕ Active coronary artery disease (defined as unstable angina or a positive cardiac stress test). Subjects with a history of coronary artery disease may be included if they have had a normal stress test within 60 days of enrollment or are determined by a cardiologist to be of acceptable perioperative risk.
- ✕ Uncontrolled hypertension defined as \>140/90 and not cleared for surgery at the time of consent.
Where it's recruiting
Illinois
Chicago
Michigan
Ann Arbor
Missouri
St Louis
Nebraska
Omaha
New Jersey
Basking Ridge · Middletown · Montvale · New Brunswick
New York
Commack · Harrison · New York · Uniondale
Pennsylvania
Pittsburgh
Source: ClinicalTrials.gov · NCT06057935 · last updated 2026-07-21