Total Periarticular Infiltration Vs Posterior Periarticular Infiltration Plus PENG Block for Hip Analgesia
Eligible age
18–80 yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
No
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About this study
In a recent study, direct periarticular local anesthetic infiltration (PAI) showed a greater incidence of early quadriceps weakness (33% at 3 hours and 13% at 6 hours) than pericapsular nerve group block (PENGB) in total hip arthroplasty (THA) but, in turn, demonstrated a statistically significant better pain control. Additionally, PENGB could not completely circumvent motor compromise either, particularly at 3 hours (20% incidence), probably secondary to an injectate migration towards the femoral nerve. Posteriorly to this publication, a cadaveric trial looking into the maximum effective volume that spared the femoral nerve resulted in 13.2 mL. This newer evidence led to the design of a strategy that combines both interventions, aiming to obtain the best of them and have a solid alternative for those cases where very early mobilization is pursued. Thus, it is hypothesized that posterior PAI added to a low-volume PENGB (10mL) represents a superior alternative to PAI in terms of strength preservation and provides effective analgesia during the first 24 postoperative hours after THA.
Sponsor: University of Chile
You may qualify if…
- ✓ American Society of Anesthesiologists classification 1-3
- ✓ Body mass index between 20 and 35 (kg/m2)
You may not qualify if…
- ✕ Adults who are unable to give their own consent
- ✕ Pre-existing neuropathy (assessed by history and physical examination)
- ✕ Coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. platelets ≤ 100, International Normalized Ratio ≥ 1.4 or prothrombin time ≥ 50)
- ✕ Renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. creatinine ≥ 100)
- ✕ Hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work-up i.e. transaminases ≥ 100)
- ✕ Allergy to local anesthetics (LAs) or morphine
- ✕ Pregnancy
- ✕ Prior surgery in the inguinal area corresponding surgical side
Source: ClinicalTrials.gov · NCT06075004 · last updated 2025-01-17