RecruitingType 2 DiabetesKetone Body MetabolismKetones, Metabolism
Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function
Eligible age
18–80 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo supplement (made with standard food ingredients that do not contain ketone esters).
Sponsor: Ohio State University
You may qualify if…
- ✓ 1. Age ≥ 18 years old and ≤ 80 years old
- ✓ 2. Type II Diabetes Mellitus
- ✓ 3. Stable medical therapy for at least 1 months as determined by the treating physician (no plan to change between the two testing sessions)
- ✓ 4. Dose of oral diuretics changes allowed, but must be stable for 1 week prior to randomization
- ✓ 5. Body Mass Index (BMI) ≥ 25
- ✓ 6. Ability to participate in exercise treadmill testing (only if CPET is performed)
- ✓ 7. Ability to sign written consent
You may not qualify if…
- ✕ 1. Women who are pregnant, current breast-feeding, or have intention to become pregnant while in the trial
- ✕ 2. Known allergy or sensitivity to Gadolinium based contrast agents
- ✕ 3. Implanted pacemaker, cardioverter defibrillator, cardiac resynchronization therapy, left ventricular assist device
- ✕ 4. Other metallic implants/aneurysm clips that are contraindicated in MRI
- ✕ 5. Claustrophobia
- ✕ 6. History of severe kidney disease with eGFR\<30 ml/kg/1.73m2
- ✕ 7. Type I diabetes
- ✕ 8. History of diabetic ketoacidosis
Where it's recruiting
Ohio
Columbus
Source: ClinicalTrials.gov · NCT06078683 · last updated 2026-04-03