RecruitingOsteoarthritis, KneeTotal Knee ArthroplastyChronic Postsurgical Pain
Reducing Perioperative Oxidative Stress to Prevent Postoperative Chronic Pain Following Total Knee Arthroplasty
Eligible age
50+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
This is a prospective randomized controlled trial that will assess preoperative, perioperative, and long-term oxidative stress (OS); pain; and functional outcomes over a 12 month period and test the hypothesis that a potent antioxidant intervention (glycine + N-acetyl-cysteine(GlyNAC)) reduces oxidative stress and chronic post surgical pain (CPSP) in patients undergoing total knee arthroplasty (TKA).
Sponsor: Vanderbilt University Medical Center
You may qualify if…
- ✓ Age 50 or older
- ✓ Intact cognitive status and ability to provide informed consent (based on cognitive screening with the Mini Mental State Examination)
- ✓ Ability to read and write in English sufficiently to understand and complete study questionnaires
- ✓ Undergoing unilateral primary TKA
- ✓ Medical diagnosis of osteoarthritis
- ✓ Past 24 hour worst numeric rating scale (NRS) pain of at least 4/10.
You may not qualify if…
- ✕ Diagnosis of pre-existing neuropathy
- ✕ Untreated hypo/hyperthyroidism
- ✕ Untreated heart disease
- ✕ Alanine transaminase/aspartate transaminase \>2x upper-limit of normal range
- ✕ serum creatinine \>1.5 mg/dl
- ✕ Pregnancy
- ✕ Complex Regional Pain Syndrome (CRPS) diagnosis prior to undergoing TKA
- ✕ Presence of lower extremity vascular disease, inflammatory or autoimmune disorders, or malignancy
Where it's recruiting
Tennessee
Nashville
Source: ClinicalTrials.gov · NCT06083480 · last updated 2025-12-11