RecruitingAcquired Brain InjuryMild Cognitive ImpairmentMild Neurocognitive Disorder

Impact of Intensive Computerized Cognitive Training

Eligible age

25–65 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

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To investigate factors that predict cognitive enhancement following engagement in an intensive Computerized Cognitive Training Protocol.

Sponsor: Brigham and Women's Hospital

✓ Patient of the Mass General Brigham Health System with primary attention and executive functioning difficulties and/or a diagnosis of mild cognitive disorder or mild neurocognitive disorder (non-amnestic profile), due to an acquired brain injury (ABI) sustained at least 12 months prior to study contact.
✓ Ages 25-65 years old
✓ Proficiency in English
✓ Willing and able to complete all study-related activities for 12 months, including travel to Brigham and Women's Hospital (Boston) for four in-person assessment visits and two serum and saliva sample collections.
✓ Access to a computer with webcam and stable internet.
✓ A reliable study informant who can complete one questionnaire about participant's cognition/daily functioning, at four time points.

✕ History of alcohol or substance abuse, or dependence, within the past 2 years, as per DSM-5 criteria.
✕ High likelihood of an underlying progressive neurodegenerative disorder.
✕ Evidence of moderate to severe cognitive disorder, based on a score of 21 or less on the Mini-Mental Status Examination (MMSE) (Tombaugh \& McIntyre, 1992).
✕ Patient Health Questionnaire (PHQ)-9 (Kroenke et al., 2010) Score ≥ 19, unless deemed by treating provider not to have active depression (e.g., adjustment disorder, grief reaction).
✕ Active psychotic symptoms.
✕ Severe sensory losses such that participants would unlikely be able to participate in the study training, even with substantial accommodations (self-report of extreme difficulty reading ordinary newspaper print or a performance-tested corrected vision test score of worse than 20/30).
✕ Communication difficulties that prevent the participant from effectively participating in this highly interactive study protocol (based on interviewer's rating of a person's ability to be understood and to understand others).
✕ Current participation in a pharmacological, or other interventional research trial.

Boston

Source: ClinicalTrials.gov · NCT06130735 · last updated 2025-11-05