Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulation for participants that are within a unipolar major depressive episode and also have high symptoms of anhedonia.
Sponsor: Florida State University
You may qualify if…
- ✓ Between the ages of 18 and 65
- ✓ Able to provide informed consent
- ✓ Have normal to corrected vision
- ✓ Willing to comply with all study procedures and be available for the duration of the study
- ✓ Speak and understand English
- ✓ Mild suicide risk as determined by the Hamilton Depression Rating Scale (HAM-D; less than 3 for the suicidality item) and non-existent or mild risk according to the Depression Symptom Index Suicidality Subscale (DSI-SS).
- ✓ Patient Health Questionnaire (PHQ-8) greater than or equal to 8 prior to the first session
- ✓ Snaith Hamilton Pleasure Scale (SHAPS) greater than 33 at the first session
You may not qualify if…
- ✕ ADHD (currently under treatment)
- ✕ Neurological disorders and conditions including, but not limited to history of epilepsy; seizures, except childhood febrile seizures; dementia; history of stroke; Parkinson's disease, multiple sclerosis, cerebral aneurysm; brain tumors
- ✕ Medical or neurological illness or treatment for a medical disorder that could interfere with study participation. For example, unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment
- ✕ Prior brain surgery
- ✕ Any brain devices/implants including cochlear implants and aneurysm clips, cardiac pacemaker, or any other implanted electronic device
- ✕ History of current traumatic brain injury
- ✕ Pregnancy (for females)
- ✕ Current severe substance use disorder
Where it's recruiting
Tallahassee
Source: ClinicalTrials.gov · NCT06132581 · last updated 2026-03-11