RecruitingObesityOverweight

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Eligible age

18–75 yrs

Accepts

All genders

Locations

22 states

Healthy volunteers

See if you qualify for this study

Answer a few quick questions about your location and health. Takes about a minute.

Check my eligibility →

About this study

The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.

Sponsor: Eli Lilly and Company

You may qualify if…

✓ Have a body mass index (BMI)
✓ ≥30 kilogram/square meter (kg/m²), or
✓ ≥27 kg/m² and \<30 kg/m², or with at least 1 weight-related comorbidity
✓ Have had a stable body weight for the 3 months prior to randomization (\<5%) body weight gain and/or loss.

You may not qualify if…

✕ Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening.
✕ Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma.
✕ Have poorly controlled hypertension.
✕ Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease.
✕ Have any of the following cardiovascular conditions within 3 months prior to screening:
✕ acute myocardial infarction
✕ cerebrovascular accident (stroke)
✕ unstable angina, or