Cannabis for Palliative Care in Cancer
Eligible age
25+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Many cancer patients suffer from pain, sleep, and mood problems and are using cannabis to relieve these symptoms. Cannabis may provide such relief but may also produce negative side effects including cognitive impairment, an especially problematic issue for cancer patients, indicating more research on cannabis use in the cancer context is required. In this endeavor, the present study seeks to compare the use of hemp-derived CBD (Cannabidiol) with and without THC (Delta-9-tetrahydrocannabinol) versus placebo on measures of sleep, pain, mood, subjective and objective cognitive functioning, and quality of life within 185 cancer patients.
Sponsor: University of Colorado, Boulder
You may qualify if…
- ✓ 1. Able to provide informed consent
- ✓ 2. Aged ≥25 years at Visit 1 (Baseline)
- ✓ 3. Have a diagnosis of any solid tumor type and is currently undergoing or has undergone either curative or palliative treatment in the past 18 months
- ✓ 4. Currently experiencing symptoms of sleep problems, pain, and/or mood disturbance (i.e., depression, anxiety)
- ✓ 5. Desire to use cannabis to treat their symptoms
- ✓ 6. Must not have been regularly using any cannabis products (more than 3x/month) in the last 6 months
- ✓ 7. Willing to practice acceptable methods of birth control until completing study medication
You may not qualify if…
- ✕ 1. Report of illegal drug use (e.g., cocaine, methamphetamine) in the past 90 days
- ✕ 2. Current use of anti-epileptic medications (e.g., clobazam, sodium valproate, lamotrigine)
- ✕ 3. Current use of medications known to have major interactions with Epidiolex (e.g., buprenorphine, leflunomide, levomethadyl acetate, lomitapide, mipomersen, pexidartinib, propoxyphene, sodium oxybate, teriflunomide)
- ✕ 4. Current use of anti-psychotic medications
- ✕ 5. Current use of potent CYP2C19 or CYP3A4 inducers (e.g., Rifampin, apalutamide, carbamazepine, enzalutamide, ivosidenib9, lumacaftor, ivacaftor, phenytoin, St. John's wort, Fosphenytoin, Mitotane, Phenobarbital, Primidone)
- ✕ 6. Liver function tests (Alanine transaminase \[ALT\] and Aspartate transaminase \[AST\]) levels ≥2x the upper normal limits
- ✕ 7. Moderate or severe liver disease
- ✕ 8. Past or current diagnosis, or family history of diagnosis, of psychosis; current major psychiatric illness, such as bipolar disorder, major depression, or schizophrenia
Where it's recruiting
Aurora
Source: ClinicalTrials.gov · NCT06266611 · last updated 2025-08-01