RecruitingStaphylococcus AureusMicrobial ColonizationNeonatal Infection

Comparing Single Versus Repeat NMT on the Diversity of the Neonatal Nasal Microbiome

Eligible age

0–60 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

This study aims to determine whether a parent-to-child nasal microbiota transplant (NMT) can seed and engraft parental organisms into the neonatal microbiome and increase the neonatal microbiome diversity.

Sponsor: Johns Hopkins University

You may qualify if…

✓ Neonate:
✓ 1. Neonate has anticipated NICU length of stay \> 7 days
✓ 2. Neonate ≥25 weeks gestation
✓ 3. At least one parent/adult provider not colonized with S. aureus (as determined by baseline screening)
✓ 4. Neonate is not colonized with S. aureus on baseline screening
✓ Parent/Adult provider:
✓ 1\. Parent/Adult provider is able to provide informed consent

You may not qualify if…

✕ Neonate:
✕ 1. Neonate has had a prior clinical or surveillance culture grow S. aureus
✕ 2. Neonate is a ward of the State
✕ 3. Neonate with antenatal suspicion for immunodeficiency (e.g. sibling with known immunodeficiency, genetic syndrome with known associated immunodeficiency)
✕ 4. Neonate cannot have nasal swabs collected (due to anatomic or other clinical intervention, including nasal packing)
✕ Parent/Adult provider:
✕ 1. Parent/adult provider had positive COVID-19 test in prior 21 days
✕ 2. Parent/adult provider with signs or symptoms of respiratory illness (e.g. runny nose, congestion, fever, cough)

Where it's recruiting

Maryland

Baltimore

Source: ClinicalTrials.gov · NCT06283355 · last updated 2026-06-08