RecruitingObstructive Sleep Apnea
Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The purpose of this study is to determine if the treatment of Obstructive sleep apnea (OSA) by hypoglossal nerve stimulation (HGNS) will alter glucose metabolism. The study team will also determine if the treatment of Obstructive sleep apnea (OSA) by (hypoglossal nerve stimulation) HGNS will alter predictors of cardiovascular outcomes.
Sponsor: University of Chicago
You may qualify if…
- ✓ Overweight or obese males and females BMI 25 kg/m2 to 40 kg/m2
- ✓ Age 18 years and older
- ✓ Diagnosed with obstructive sleep apnea by Apnea-Hypopnea Index \>15 events/hr using 4% oxygen desaturation criteria and \< 25% central events/hr on prior sleep testing Data can be derived from home sleep testing or in-lab polysomnogram
- ✓ Not able to use positive airway pressure \>4 hours for 5 nights/week or unwilling to use positive airway pressure
You may not qualify if…
- ✕ Insulin-dependent Diabetes
- ✕ Inability to undergo in-lab polysomnography or home sleep testing
- ✕ Central Nervous System (CNS) disease with impairment of cognitive function (dementia) and/or muscle paresis, such as stroke
- ✕ Currently pregnant, trying to get pregnant or nursing
- ✕ age \< 18 years
- ✕ Regular and adherent CPAP use per clinical guidelines
- ✕ Current night shift or rotating shift work
- ✕ Diagnosis of another sleep disorder (e.g. periodic limb movement disorder)
Where it's recruiting
Illinois
Chicago
Source: ClinicalTrials.gov · NCT06317701 · last updated 2026-01-28