3-D Tractography FUS Ablation for Essential Tremor
Eligible age
22+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The investigators propose to advance Vim-FUSA (Ventral Intermediate Nucleus - Focused Ultrasound Ablation) with the support of 3-D tractography, a neuroimaging technique to visually represent nerve tracts within the brain. The investigators hypothesize that 3-D tractography Vim-FUSA will improve the Vim ablation compared to standard Vim-FUSA and prove safe and feasible in the clinical setting. The investigators also hypothesize that intraoperative magnetic resonance (i-MR) monitoring will differentiate ablated tissue from immediate perilesional edema and accurately predict the Vim-FUSA clinical outcomes.
Sponsor: University of North Carolina, Chapel Hill
You may qualify if…
- ✓ Diagnosis of moderate to severe ET agreed upon by at least two movement disorder trained physicians
- ✓ Symptoms refractory to at least two medications
- ✓ Stable medication regimen for at least 4 weeks prior to screening
- ✓ Willing and able to participate in all follow-up visits
- ✓ Willing and able to undergo MR imaging.
You may not qualify if…
- ✕ Uncontrolled hypertension
- ✕ Medically unstable coronary artery disease
- ✕ Coagulopathy, anticoagulant therapy, or inability to temporarily stop any antithrombotic medication
- ✕ Tremor disorders other than ET
- ✕ Unwilling or unable to undergo tremor surgery while awake
- ✕ Significant and non-correctible motion artifact in imaging
- ✕ Pregnant at the time of enrollment or preoperative evaluation
- ✕ Dementia
Where it's recruiting
Chapel Hill
Source: ClinicalTrials.gov · NCT06331052 · last updated 2026-01-20