RecruitingHepatocellular CarcinomaIntrahepatic CholangiocarcinomaCholangiocarcinoma
An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
It is sometimes difficult to precisely understand whether a primary liver cancer is a hepatocellular carcinoma or a cholangiocarcinoma. The researchers will develop and validate a liquid biopsy, based on exosomal content analysis and powered by machine learning, to help clinicians differentiate these two cancers before surgery.
Sponsor: City of Hope Medical Center
You may qualify if…
- ✓ A histologically confirmed diagnosis of hepatocellular carcinoma
- ✓ A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma
- ✓ Received standard diagnostic and staging procedures as per local guidelines
- ✓ Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment
You may not qualify if…
- ✕ Lack of or inability to provide informed consent
- ✕ Synchronous hepatocellular carcinoma and intrahepatic cholangiocarcinoma
- ✕ Primary liver cancer other than hepatocellular carcinoma or intrahepatic cholangiocarcinoma
- ✕ Secondary liver cancer
Where it's recruiting
California
Duarte
Source: ClinicalTrials.gov · NCT06342414 · last updated 2026-07-07