Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants
Eligible age
0.1–0.4 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
Yes
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About this study
Around 50% of infants born extremely preterm develop a chronic lung disease known as bronchopulmonary dysplasia of which some infants will also develop pulmonary hypertension of which 50% of children will die before the age of 2. Physicians are currently limited in their ability to select the most appropriate oxygen targets that will improve outcomes in infants with this condition. This clinical trial will determine whether using different amounts of oxygen improve outcomes in infants with this disease.
Sponsor: University of Alabama at Birmingham
You may qualify if…
- ✓ Between 22w 0/7d and 31w 6/7d gestation at birth
- ✓ Diagnosed with echocardiographic pulmonary hypertension (1) \>20% flow of blood across the PDA from the pulmonary to arterial circulation, (2) end-systolic flattening of the interventricular septum (eccentricity index \>1.3), or (3) right ventricular pressure estimates ≥ 35 mm Hg
- ✓ Receiving supplemental oxygen
- ✓ Have mature retinas
You may not qualify if…
- ✕ Major congenital anomalies
Where it's recruiting
Birmingham
New Haven
Source: ClinicalTrials.gov · NCT06373289 · last updated 2026-08-26