CBD for Pain Following Orthopedic Shoulder Surgery
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The goal of the study is to learn if Epidiolex (cannabidiol) works as a additional pain medication in patients who have had orthopedic shoulder surgery. It is also to learn about safe dosages and identify any side effects after surgery. Researchers will compare Epidiolex to a placebo solution to see if Epidiolex lowers pain after shoulder surgery. Participants will: * track their pain and what medications they use every day in a provided pain diary. A researchers will call every seven days to check on the participant and diary. * Complete two short surveys. Once before surgery and once after. * Have bloodwork tested after surgery
Sponsor: The Methodist Hospital Research Institute
You may qualify if…
- ✓ Above the age of 18 years old
- ✓ Undergoing a rotator cuff repair surgery
- ✓ Receiving standard anesthesia during surgery
- ✓ If a subject is of reproductive potential, they must be on effective contraception one month prior, during treatment, and one month following treatment.
You may not qualify if…
- ✕ Under the age of 18 years old
- ✕ History of revision shoulder arthroplasty
- ✕ History of liver disease or impairment
- ✕ Are currently taking valproate or clobazam
- ✕ Are currently taking a moderate/strong CYP3A4 or CYP2C19 inhibitor
- ✕ Are currently taking a strong CYP3A4 or CYP2C19 inducer
- ✕ Are currently taking narcotics
- ✕ History of substance/alcohol abuse
Where it's recruiting
Houston
Source: ClinicalTrials.gov · NCT06381791 · last updated 2026-04-16