Nightmare Deconstruction and Reprocessing vs. NightWare Wristband
Eligible age
22–64 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The overall goal of this Phase IIa randomized controlled pilot trial is to assess the potential efficacy of two emerging treatments for post-trauma nightmares and to test the feasibility of study design and methods. Symptom change will be assessed in two treatment arms: (1) Nightmare Deconstruction and Reprocessing (NDR), an exposure-based psychotherapy; and (2) NightWare (NW), a non-exposure approach using a wristband device. The investigators will also assess the feasibility of circadian-dependent blood sampling and use of another wristband to collect physiologic data. Specific aims are: (1) Compare evidence of how well participants tolerate and comply with the two treatments and test feasibility of methods and procedures; (2) Collect additional evidence of the potential efficacy of two contrasting non-pharmacologic approaches to treating posttraumatic nightmares; (3) Explore the operational stress index (OSI) as a reliable, objective measure of sleep disturbance and nightmare events.
Sponsor: Uniformed Services University of the Health Sciences
You may qualify if…
- ✓ Active duty service members and veterans
- ✓ Minimum symptom severity:
- ✓ Has had at least 1 nightmare per week for the past month
- ✓ Has a minimum ISI score of 8
- ✓ If taking medications for PTSD, depression, anxiety, or insomnia, must be on stable dose for 8 weeks.
You may not qualify if…
- ✕ Serious risk of suicide
- ✕ Psychosis, bipolar disorder, or alcohol or substance use disorder
- ✕ Untreated moderate to severe sleep apnea
- ✕ Use of synthetic glucocorticoid beta blockers, prazosin, or varenicline
- ✕ Current evidence-based or experimental psychotherapy directly targeting nightmares, insomnia, or PTSD
- ✕ Inability to recall nightmare content
- ✕ Inability to wear wristband or sync wristband data
- ✕ Inability to comply with blood draws
Where it's recruiting
Bethesda
Source: ClinicalTrials.gov · NCT06399874 · last updated 2025-03-30