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RecruitingMelanomaClear-Cell Renal-Cell Carcinoma (ccRCC)Advanced Solid Tumors

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

Eligible age

18+ yrs

Accepts

All genders

Locations

8 states

Healthy volunteers

No

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About this study

This study is researching an experimental drug called REGN10597 alone or in combination with another drug called cemiplimab (called "study drug(s)"). The study is focused on patients with certain solid tumors that are in an advanced stage. The aim of the study is to see how safe, tolerable, and effective the study drug(s) are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug(s) * How much study drug(s) is in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)

Sponsor: Regeneron Pharmaceuticals

Where it's recruiting

California

Los Angeles · San Francisco

Connecticut

North Haven

Illinois

Chicago

Michigan

Grand Rapids

New York

Lake Success

North Carolina

Chapel Hill

Pennsylvania

Pittsburgh

Texas

Houston · San Antonio

Source: ClinicalTrials.gov · NCT06413680 · last updated 2026-04-28

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine G · TrialPath