CBD for Knee Osteoarthritis
Eligible age
40–75 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population. Many physically active Americans have reported pain-relieving effects of cannabidiol (CBD) that can reduce or eliminate use of nonsteroidal anti-inflammatory drugs (NSAIDs) for activity-related pain with minimal to no side effects. Long-term use of over-the-counter medications, including NSAIDs, can pose a significant health risk, and therefore clinical research on the safety and efficacy of CBD is needed.
Sponsor: University of Florida
You may qualify if…
- ✓ 1. established clinical diagnosis of knee osteoarthritis (KOA)
- ✓ 2. moderate to severe knee pain (≥4/10) with physical activity in one or both knees
You may not qualify if…
- ✕ 1. pregnant (urine pregnancy test) or lactating
- ✕ 2. current cannabis (THC and/or CBD) use (urine drug screen)
- ✕ 3. any prior or ongoing medical condition that, in the investigators' opinion, could adversely affect the safety of the subject
- ✕ 4. any major surgery within 3 months prior to recruitment or planned orthopedic surgery for any time during this study which would interfere with the ability to report pain or quality of life outcome measures
- ✕ 5. any exposure to another investigational drug within 3 months prior to screening
- ✕ 6. BMI ≥ 45
- ✕ 7. current use of any enzyme-modifying drugs, including strong inhibitors or strong inducers of cytochrome P (CYP) enzymes
- ✕ 8. history of:
Where it's recruiting
Gainesville
Source: ClinicalTrials.gov · NCT06414473 · last updated 2025-09-17