RecruitingPreDiabetes
Insulin and Insulin Pulses During Fasting
Eligible age
25–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
Sponsor: Mayo Clinic
You may qualify if…
- ✓ people with normal or impaired fasting glucose and normal or impaired glucose tolerance
You may not qualify if…
- ✕ 1. HbA1c \> 6.5%
- ✕ 2. BMI ≥ 35 Kg/M2
- ✕ 3. Use of any glucose-lowering agents including metformin or sulfonylureas.
- ✕ 4. For female subjects: positive pregnancy test at the time of enrollment or study
- ✕ 5. History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
- ✕ 6. Active systemic illness or malignancy.
- ✕ 7. Symptomatic macrovascular or microvascular disease.
- ✕ 8. Hematocrit \< 35%
Where it's recruiting
Minnesota
Rochester
Source: ClinicalTrials.gov · NCT06424015 · last updated 2025-10-01