RecruitingPleural Infection
Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The purpose of this study is to see if there is any benefit in adding saline irrigation through a chest tube to the standard course of treatment for people diagnosed or suspected of having a pleural space infection.
Sponsor: Mayo Clinic
You may qualify if…
- ✓ Purulent pleural fluid versus pleural fluid analysis demonstrating pH \<7.2, glucose \<60 mg/dL, positive Gram stain, or positive pleural fluid culture versus multiseptated pleural effusion with infection at top of differential diagnosis
- ✓ Patients initiating intrapleural lytic therapy under the care of the Interventional Pulmonary consult service at Mayo Clinic in Rochester, MN
You may not qualify if…
- ✕ Unwillingness to give informed consent
- ✕ Patients with known bleeding diathesis
- ✕ Platelet count \<50,000 per μL
- ✕ INR \>2.2 (of note, INR can be allowed to drift down or be reversed pharmacologically prior to initiation of intrapleural lytics/saline)
- ✕ Current use of systemic anticoagulation or antiplatelet therapy without the ability to hold therapy for the recommended amount of time prior to an invasive procedure (aspirin monotherapy is acceptable)
- ✕ Pregnant or nursing females, or females of child-bearing potential who decline a pregnancy test prior to enrollment
- ✕ Incarcerated patients
- ✕ Presence of ipsilateral bronchopleural fistula
Where it's recruiting
Minnesota
Rochester
Source: ClinicalTrials.gov · NCT06434324 · last updated 2026-03-30