Prevention of Progression of Prediabetes, Obesity and CV Risk
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
The investigators are studying how to help people with prediabetes (Pre-DM) and obesity. The goal is to use new and affordable treatments to bring blood sugar levels back to normal and help participants to lose weight. The investigators also want to reduce participants risk of heart problems. The study team will look at how these treatments affect metabolism and other body functions to help find new ways to treat diabetes and obesity in the future.
Sponsor: The University of Texas Health Science Center at San Antonio
You may qualify if…
- ✓ 1. Patients will have an established diagnosis of pre-Diabetes Mellitus (DM) before the screening visit, documented by an acceptable modality in the last 6 months.
- ✓ 2. Age ≥ 18 years old
- ✓ 3. Body Mass Index (BMI)=25-40 kg/m2
- ✓ 4. Glycated Hemoglobin (HbA1c) = 5.7-6.4%
- ✓ 5. Blood Pressure (BP) \<160/100
- ✓ 6. Estimated Glomerular Filtration Rate (eGFR) ≥30 ml/min•1.73m2
- ✓ 7. Body weight must be stable (±5 pounds) over the last 3 months.
- ✓ 8. Oral diuretics, if prescribed to the patient according to local guidelines and discretion of the investigator, should be stable for at least 1 week prior to randomization.
You may not qualify if…
- ✕ 1. Patients currently on one of the selected therapies
- ✕ 2. Extended diagnoses with Type 2 Diabetes
- ✕ 3. Pregnancy, lactation, women of childbearing age (WOCBA) unwilling to use contraception
- ✕ 4. Known allergy/sensitivity to study drugs or their ingredients
- ✕ 5. Major oncologic diagnosis in the last 5 years
- ✕ 6. Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements
- ✕ 7. Inability or unwillingness of individual or legal guardian/representative to give written informed consent
- ✕ 8. Major organ or metabolic diseases, or physical limitations that will not allow the subject to complete the study
Where it's recruiting
San Antonio
Source: ClinicalTrials.gov · NCT06446531 · last updated 2025-11-12