Hemodynamic Management Following Acute Traumatic Spinal Cord Injury
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI). The hemodynamic management strategies assessed include targeting a mean arterial blood pressure (MAP) goal of 85-90 mmHg, targeting a spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg, or targeting normal hemodynamics, which is a MAP goal of ≥65 mmHg.
Sponsor: The University of Texas Health Science Center, Houston
You may qualify if…
- ✓ Traumatic spinal cord injury
You may not qualify if…
- ✕ Patients with an injury from a trauma that penetrates the spinal cord (i.e., gunshot or knife wound resulting in cord transection)
- ✕ Preexisting neurologic or spinal cord injury
- ✕ Severe traumatic brain injury as measured by a best resuscitated Glasgow Coma Scale (GCS) score of \<8 at 24 hours following injury
- ✕ Presence of traumatic injuries that preclude spine surgery within 24 hours of presentation
- ✕ Concomitant injury/illness requiring targeted blood pressure management (e.g., injury to the aorta, aortic dissection, hemorrhagic stroke)
- ✕ Preexisting history of neuromotor disorders (i.e., cerebral palsy, Parkinson disease, etc.)
- ✕ Not expected to survive \>24h
- ✕ Cord transection identified by radiologist and agreed upon by the spine surgery team
Where it's recruiting
Houston
Source: ClinicalTrials.gov · NCT06451133 · last updated 2024-12-11