The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
Eligible age
18–29 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The overall purpose of this study is to understand the role of disrupted sleep in the association of exposure to early life adversity (adverse childhood experiences (ACEs)) with vascular endothelial (dys)function. In Aim 1 (The Iowa ACEs and Sleep Cohort Study), the investigators will utilize a cross-sectional cohort design with a state-of-the-art translational approach. Participants will be recruited to objectively characterize the degree to which lower sleep quality and quantity contribute to ACEs-related endothelial dysfunction, inflammation, and oxidative stress in young adults using: 1. rigorous at home sleep monitoring using 7-nights of wrist actigraphy and 2 nights of home-based polysomnography to objectively measure sleep quality (sleep efficiency, wakefulness after sleep onset and sleep depth), and total sleep duration, 2. in vivo assessment of endothelial function via flow-mediated dilation testing, and 3. in vitro determination of endothelial cell inflammation and oxidative stress from biopsied endothelial cells. This study to achieve this Aim. In Aim 2, approximately 70 eligible participants from Aim 1 (The Iowa ACEs and Sleep Cohort Study) will then be randomized to either a 6-week behavioral sleep intervention (cognitive behavioral therapy for insomnia) or a wait-list control to determine the mechanistic contribution of sleep disruption to vascular dysfunction in young adults with moderate-to-high exposure to adverse childhood experiences (ACEs). Following the intervention, participants will again complete: 1. rigorous at home sleep monitoring using 7-nights of wrist actigraphy and 2 nights of home-based polysomnography to objectively measure sleep quality (sleep efficiency, wakefulness after sleep onset and sleep depth), and total sleep duration, 2. in vivo assessment of endothelial function via flow-mediated dilation testing, and 3. in vitro determination of endothelial cell inflammation and oxidative stress from biopsied endothelial cells.
Sponsor: Nathaniel Jenkins
You may qualify if…
- ✓ 1. 18-29 years of age
- ✓ 2. SBP \<129 and DBP \<90 mmHg
- ✓ 3. Body Mass Index \> 18.5 kg/m2 and \<35 kg/m2
- ✓ 4. Willing to complete in-home sleep studies
- ✓ 1. 18-29 years of age
- ✓ 2. SBP \<129 and DBP \<90 mmHg
- ✓ 3. Body Mass Index \> 18.5 kg/m2 and \<35 kg/m2
- ✓ 4. Willing to complete in-home sleep studies
You may not qualify if…
- ✕ 1. Currently undergoing treatment for a sleep disorder or diagnosed with restless leg syndrome, hypersomnia, parasomnia or narcolepsy, or obstructive sleep apnea
- ✕ 2. Currently performing overnight shift work
- ✕ 3. Lifetime history of any psychiatric disorder with psychotic features or bipolar disorder, currently undergoing treatment for substance-induced mood disorder
- ✕ 4. Endorsed suicidal ideation as indicated by a Moderate or High risk determination on the Columbia Suicide Risk Protocol
- ✕ 5. Diagnosed neurological disorder or illness affecting the central nervous system
- ✕ 6. Diagnosed acute or chronic autoimmune disease or chronic inflammatory condition
- ✕ 7. Current or previous cancer diagnosis
- ✕ 8. History of moderate or severe traumatic brain injury
Where it's recruiting
Iowa City
Source: ClinicalTrials.gov · NCT06454344 · last updated 2025-12-11