Motor Recovery Through Plasticity-Inducing Cortical Stimulation
Eligible age
22–75 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
Using the CorTec Brain Interchange (BIC) System, we will examine the effect of a plasticity-inducing therapy regime on the rehabilitation of upper limb impairment post-stroke. This study's main objective is to implement and evaluate neuroplasticity-inducing stimulation. The stimulation methods for inducing neuroplasticity have been selected based on prior preclinical and intraoperative work that has shown promise in providing rehabilitative benefits for stroke patients. We will be structuring this study as an open prospective feasibility study.
Sponsor: University of Washington
You may qualify if…
- ✓ 22-75 years of age
- ✓ History of ischemic stroke
- ✓ Minimum 6 months post-ischemic cortical stroke
- ✓ Levels of hemiparesis that warrant surgical intervention (upper limb impairment)
- ✓ Able to participate in a meaningful way in rehabilitation (defined by upper extremity Fugl-Myer (UEFM) score of 25-45
- ✓ Disability measured between 3 and 4 on the modified Rankin Scale
- ✓ Minimum of 30% preservation of the corticospinal pathways in MRI imaging
- ✓ Observable motor output of the upper limb in response to TMS delivered to the motor cortex
You may not qualify if…
- ✕ Unable to discontinue anti-platelet medication for 7 days pre- and 3 days post-op
- ✕ On therapeutic anticoagulation
- ✕ A history of unprovoked deep vein thrombosis or any pulmonary embolus
- ✕ The presence of a bleeding disorder which significantly increases the chances that the patient will have a hemorrhagic complication in relation to study procedures.
- ✕ Other medical history indicating increased risk of thrombosis per investigator discretion
- ✕ Any history of seizures
- ✕ Pregnancy
- ✕ Geriatric Depression Score greater than 10
Where it's recruiting
Seattle
Source: ClinicalTrials.gov · NCT06506279 · last updated 2026-04-13