RecruitingDiabetes Mellitus Type 2, Childhood-Onset

DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

Eligible age

8–15 yrs

Accepts

All genders

Locations

14 states

Healthy volunteers

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About this study

The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes.

Sponsor: George Washington University

You may qualify if…

✓ Screening will occur to enrich the yield of individuals who are highly predisposed to develop youth-onset T2D and include those with all of the following criteria:
✓ Overweight or obesity with BMI ≥85th percentile
✓ Age 8-13 year for girls, 9-15 year for boys (inclusion younger for girls as puberty tends to start a year earlier in girls)
✓ Tanner Stage 2, 3, or 4
✓ Elevated HbA1c 5.5-6.4%

You may not qualify if…

✕ An individual who meets any of the following criteria will be excluded from participation:
✕ Diabetes based on history, or HbA1c ≥6.5% in the medical record or at screening
✕ Unable/unwilling to provide consent/participate fully
✕ Conditions predisposing to diabetes or altering the trajectory of puberty
✕ Medications affecting glucose dynamics during the screening and enrollment period
✕ Prior treatment with insulin
✕ Use of glucagon-like peptide-1 (GLP-1) receptor agonist or any weight loss medications in the 6 weeks prior to enrollment
✕ Planning treatment with glucagon-like peptide-1 (GLP-1) receptor agonist or any weight loss medications