Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous ventricular arrhythmias. The investigators aim to study: 1. the prevalence and mechanism of inducible ventricular tachycardia 2. pace-mapping to define the site of origin of ventricular arrhythmias 3. voltage mapping to define low voltage scar substrate in the basal LV to determine the risk of development of ventricular arrhythmias in patients with genetic forms of cardiomyopathy. Participants will undergo cardiac MRI before their scheduled procedure and voltage mapping during their scheduled procedure as part of data collection.
Sponsor: Vanderbilt University Medical Center
You may qualify if…
- ✓ Adults aged 18 and older
- ✓ Diagnosed with AF, frequent PVCs, or VT before age 60
- ✓ Scheduled for catheter-based AF ablation (de-novo or repeat) OR catheter-based PVC ablation OR catheter-based VT ablation
- ✓ Able to provide written, informed consent
- ✓ P/LP variant in TTN or other CM gene (cases) or identified as a genotype-negative control.
You may not qualify if…
- ✕ Diagnosed with a genetic CM or arrhythmia syndrome prior to ablation procedure
- ✕ VUS in 'possibly pathogenic' subgroup (control group only)
- ✕ Previous PVC or VT ablation
- ✕ LVEF \<20%
- ✕ Prosthetic mitral or aortic valve
- ✕ Contraindication to heparin
- ✕ Prior myocardial infarction
Where it's recruiting
Nashville
Source: ClinicalTrials.gov · NCT06575881 · last updated 2026-05-06