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RecruitingCannabis UseDepressionSuicidal Ideation

Cannabis, Linked Emotions, and Adolescent Risk Study

Eligible age

12–18 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

The goal of this study is to disentangle relationships between acute cannabis use and withdrawal on proximal depression and suicide risk and recovery in adolescents ages 12-18 years by incorporating time-varying patterns of substance use, mood, and SI. This project aims to guide the development of scalable, individualized, accessible, and affordable interventions aimed to reduce depression and suicide risk among adolescents.

Sponsor: Massachusetts General Hospital

You may qualify if…

  • ✓ Ages 12-18;
  • ✓ Current daily or near daily cannabis use (i.e., use ≥ 4 days per week on average; Timeline Followback);
  • ✓ Score ≥ 5 on PHQ-9;
  • ✓ Access to an internet-capable smartphone (iOS or Android);
  • ✓ Provision of at least 1 collateral contact for risk monitoring;
  • ✓ Provision of informed assent (or consent if 18 years or older) and parent/guardian consent if \<age 18;
  • ✓ Greater than 50% response rate to EMA prompts during the first EMA phase;
  • ✓ No immediate plan to discontinue cannabis use in the next 3 months;

You may not qualify if…

  • ✕ Any factor that impairs ability to comprehend and effectively participate, including acute intoxication at time of consent;
  • ✕ Cannabis use \>4 times/day on average (to maximize likelihood of capturing mood and SI during non-use times);
  • ✕ Inability to speak/write English fluently;
  • ✕ Gross cognitive impairment, for example due to florid psychosis, intellectual disability, developmental delay, or neurodegenerative disease;
  • ✕ Current epilepsy diagnosis;
  • ✕ Individuals who are under the legal protection of the government or state (wards of the state);
  • ✕ Response of "No" to the knowledge check question regarding EMA suicidality response time;
  • ✕ Inability to wear Fitbit device.

Where it's recruiting

Massachusetts

Boston

Source: ClinicalTrials.gov · NCT06576076 · last updated 2026-03-03

Cannabis, Linked Emotions, and Adolescent Risk Study · TrialPath