RecruitingPulmonary EmbolismPulmonary Thromboembolism

The PERSEVERE Study

Eligible age

18+ yrs

Accepts

All genders

Locations

9 states

Healthy volunteers

See if you qualify for this study

Answer a few quick questions about your location and health. Takes about a minute.

Randomized Controlled Trial of High-Risk Pulmonary Embolism Comparing FlowTriever System vs. Standard of Care

Sponsor: Inari Medical

✓ 1. Age at enrollment ≥18 years
✓ 2. Objective evidence of a proximal filling defect in at least one main or lobar pulmonary artery
✓ 3. High-risk class of acute PE
✓ 4. RV dysfunction, as defined RV/LV ratio ≥1.0
✓ 5. Willing and able to provide informed consent, or if unable, through a Legal Authorized Representative, with permitting research without prior consent as a third option (for Europe and UK sites only), provided compliance with IRB/EC approvals and adherence to regulatory, ethical and national standards

✕ 1. Prolonged cardiac arrest with loss of consciousness associated with neurological deficit.
✕ 2. Imaging evidence or other evidence that suggests, in the opinion of the Investigator, the patient is not appropriate for catheter-based intervention
✕ 3. Known pre-existing CTEPH, or CT signs of chronic PE that may point to pre-existing CTEPH
✕ 4. Recent stroke (\<14 days)
✕ 5. Recent cranial or spinal surgery (\<14 days)
✕ 6. Life-threatening active bleeding or hemorrhage into a critical area
✕ 7. Known intracranial tumor
✕ 8. End-stage medical condition with life expectancy \<3 months (irrespective of the severity of acute PE), as determined by the Investigator