Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction
Eligible age
18+ yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
The goal of this clinical trial is to learn more about mood, sleep, and activity during menopause. The main question it aims to answer is: can mood and sleep dysfunction in menopause be improved by resetting misaligned circadian rhythm through one night of strategic sleep timing adjustment and two weeks of exposure to bright light at a certain time of day? Researchers will compare sleep timing (earlier vs. later) and bright white light exposure (morning or evening) to investigate the effect of melatonin levels on mood, sleep, and activity. Participants will 1) submit urine samples to measure melatonin levels, 2) be assigned to advance or delay their sleep for one night, 3) sit in front of a light box for 30 minutes per day (morning or evening) for 14 days, 4) complete questionnaires about their mood and sleep, and 5) wear a device that will measure their activity.
Sponsor: University of California, San Diego
You may qualify if…
- ✓ Perimenopausal women with irregular menstrual cycles for at least 3 months
- ✓ Above age 18
- ✓ Experiencing at least moderate depression symptoms (i.e., score of at least 10 on PHQ-9)
You may not qualify if…
- ✕ Actively suicidal or psychotic
- ✕ History of bipolar disorder
- ✕ Staring new medications that would affect outcome measures (e.g., melatonin)
- ✕ Those in whom sleep restriction would be ill-advised (e.g., patients with epilepsy or those with occupations whose safety would be compromised).
- ✕ Women whose body mass index (BMI) exceeds the NIH criteria of \<18 or \> than 30
Where it's recruiting
San Diego
Source: ClinicalTrials.gov · NCT06678880 · last updated 2026-02-27