RecruitingInfertility, FemaleObesity
Convergent Mechanisms Underlying Reprometabolic Syndrome in Women
Eligible age
18–38 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.
Sponsor: University of Colorado, Denver
You may qualify if…
- ✓ Age 18-38
- ✓ Regular menstrual cycles every 25-35 days
- ✓ No use of reproductive hormones within the past 3 months
- ✓ No use of medications interacting with reproductive hormones
- ✓ Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
- ✓ Normal thyroid stimulating hormone, prolactin and lipid profiles
- ✓ No more than 4 hours of moderate to vigorous intensity exercise per week
- ✓ No history of chronic disease impacting reproductive hormones
You may not qualify if…
- ✕ Has diabetes
- ✕ Is a smoker
- ✕ History of venous thromboembolism or known thrombophilia
Where it's recruiting
Colorado
Aurora
Source: ClinicalTrials.gov · NCT06686537 · last updated 2026-07-21