Carotid Sinus Massage in Trendelenburg Position for Headache Relief
Eligible age
16+ yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
No
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About this study
Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types. There is growing evidence suggesting that blood pressure regulation and baroreceptor activity play a role in headache pathophysiology. Carotid sinus massage (CSM), particularly when combined with the modified Trendelenburg position, may modulate autonomic nervous system activity to relieve headache symptoms. An initial open-label pilot study (n = 17) was completed, and the results were published in a preprint server for health sciences, the Medical Research Archive (medRxiv), demonstrating the feasibility, safety, and promising preliminary efficacy of CSM+T. Based on these findings, a follow-up randomized, sham-controlled, parallel-arm trial will further evaluate the efficacy of the treatment.
Sponsor: Hospital Municipal Pedro T. Orellana
You may qualify if…
- ✓ Participants must be at least 16 years of age.
- ✓ Must have a diagnosis of one of the following, according to the International Classification of Headache Disorders (ICHD-3):
- ✓ Migraine
- ✓ Tension-type headache
- ✓ Mixed headache
- ✓ The headache episode must have started within the past 24 hours.
You may not qualify if…
- ✕ Any contraindication to carotid sinus massage, including:
- ✕ Carotid bruits
- ✕ Recent myocardial infarction
- ✕ History of stroke
- ✕ Known or suspected carotid artery stenosis
- ✕ Any contraindication to the Trendelenburg position, including:
- ✕ Increased intracranial pressure
- ✕ Respiratory distress
Source: ClinicalTrials.gov · NCT06745648 · last updated 2025-06-15