Role of Menopause in Thermoregulation
Eligible age
42–64 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
Yes
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About this study
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on the response to heat stress are unknown. In this study, the investigators will identify the role of estrogen in pre and post menopausal women on thermoregulatory responses to heat stress.
Sponsor: Penn State University
You may qualify if…
- ✓ Women ages 42-64
You may not qualify if…
- ✕ Chron's disease, diverticulitis, or similar gastrointestinal disease
- ✕ Abnormal resting exercise electrocardiogram (ECG)
- ✕ Tobacco use
- ✕ High-risk determined by the Atherosclerotic Cardiovascular Disease (CVD) Risk Factor
- ✕ Assessment
- ✕ Using hormone therapy
- ✕ Using hormonal contraceptives
Where it's recruiting
University Park
Source: ClinicalTrials.gov · NCT06798571 · last updated 2026-06-24