RecruitingPreeclampsiaPreeclampsia (PE)Preeclampsia (PE) Risk
Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia
Eligible age
18–45 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
This study's primary purpose is to determine the relationship between aspirin metabolism and markers of metabolic dysfunction among patients at risk for preeclampsia.
Sponsor: University of Tennessee Graduate School of Medicine
You may qualify if…
- ✓ Recommended aspirin for pre-eclampsia prevention by OB/GYN or MFM specialist based on ACOG and USPSTF guidelines (1 high risk factor, 2+ moderate risk factors)
- ✓ Willingness to adhere to aspirin therapy
- ✓ Willingness to undergo 2h OGTT for serum and urine collection in addition to survey collection, indirect calorimetry, body composition measures, neonatal measures, etc.
- ✓ Gestational age at enrollment \<16 weeks
- ✓ Ability to speak, read, and communicate via English
You may not qualify if…
- ✕ Type 2 Diabetes Mellitus
- ✕ Type 1 Diabetes Mellitus
- ✕ Current gestational diabetes mellitus
- ✕ Current/active platelet disorder or bleeding diathesis (thrombocytopenia of any etiology, idiopathic thrombocytopenic purpura/ITP, thrombotic thrombocytopenic purpura/TTP, von Willebrand disease, etc.)
- ✕ Thrombophilia
- ✕ Current use of NSAID for other indication (indomethacin, ibuprofen, etc.)
- ✕ Current use of other immune-modulating agents and biologics (hydroxychloroquine, azathioprine, 6-mercaptopurine, IL-6 inhibitors, etc.)
- ✕ Current or recent use of steroids
Where it's recruiting
Tennessee
Knoxville
Source: ClinicalTrials.gov · NCT06802861 · last updated 2025-09-10