RecruitingDepressionSelective Serotonin Reuptake Inhibitor

Impact of Depression on Thermoregulation

Eligible age

18–40 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who are prescribed and taking SNRIs.

Sponsor: Penn State University

You may qualify if…

✓ Non-depressed adults aged 18-40 years;
✓ OR adults aged 18-40 years with clinically diagnosed major depressive disorder according to DSM-V criteria not currently receiving antidepressant treatment;
✓ OR adults aged 18-40 years with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a selective serotonin reuptake inhibitor;
✓ OR aged 18-40 years adults with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a serotonin norepinephrine reuptake inhibitor;
✓ All participants will be asymptomatic and no signs/symptoms of disease according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription (chest pain or pressure, dizziness, joint pain, and signs of cardiovascular disease);
✓ Systolic blood pressure 140 mmHg and diastolic pressure 90 mmHg at screening;
✓ Non-diabetic
✓ Not taking any other medications that might affect the physiological variables of interest (beta blockers, tricyclic antidepressants, antipyretics, diuretics, etc.);;

You may not qualify if…

✕ BMI \> 35
✕ Are pregnant or planning to become pregnant in the next 12 months;
✕ Concurrently participate in another study involving physical activity or weight loss;
✕ Plan to have surgery or relocate outside the area within the next year;
✕ Medications that could alter cardiovascular or thermoregulatory responses to exercise (beta blockers, antipyretics, tricyclic antidepressants, diuretics, etc.);
✕ Allergy to latex or adhesive;
✕ Tobacco use;
✕ Illegal/recreational drug use;

Where it's recruiting

Pennsylvania

University Park

Source: ClinicalTrials.gov · NCT06805851 · last updated 2026-02-03