RecruitingStroke, Acute
Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients With Large Vessel OCclusion in the Angiography SuiTe
Eligible age
18+ yrs
Accepts
All genders
Locations
5 states
Healthy volunteers
No
See if you qualify for this study
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About this study
The purpose of this study is to compare two strategies for treating adults with suspected large vessel occlusion stroke within 7 hours of symptom onset. Researchers will evaluate whether direct transfer to the neurointerventional angiography suite improves recovery and reduces disability compared to the conventional approach of first being evaluated in the emergency department. The study will also assess safety and other health outcomes to guide care for stroke patients.
Sponsor: Santiago Ortega Gutierrez
You may qualify if…
- ✓ To be eligible for participation in the DIRECT trial, an individual must meet all of the following criteria:
- ✓ 1. Age: ≥ 18 years of age.
- ✓ 2. Clinical Presentation: Present to a participating TSC with signs or symptoms suggestive of acute LVO stroke.
- ✓ 3. Stroke Severity: Baseline NIHSS of 10 or higher.
- ✓ 4. Time since LKW: Time from LKW to arrival at the TSC must be within 7 hours.
- ✓ Additional criteria
- ✓ For all Interfacility Transfers:
- ✓ 1\. If imaging was performed at the outside facility, the time from the first imaging to arrival at the thrombectomy center must exceed 90 minutes.
You may not qualify if…
- ✕ An individual who meets any of the following criteria will be excluded from participation in the trial:
- ✕ 1. Time Restrictions: Presentation to a thrombectomy-capable center more than 7 hours from LSW.
- ✕ 2. Imaging Criteria for Interfacility Transfer Patients: At sites enrolling transfer patients, any patient arriving from an outside hospital with time from imaging study at the presenting hospital to arrival at the TSC not exceeding 90 minutes.
- ✕ 3. Hemorrhagic Stroke: Presence of intracranial hemorrhage on brain imaging in the conventional strategy as Heidelberg that renders thrombectomy contraindicated.
Where it's recruiting
Source: ClinicalTrials.gov · NCT06825897 · last updated 2026-03-13