RecruitingSpinal Cord Injury
The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study
Eligible age
19+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer traumatic spinal fracture and/or dislocation of the spinal column but without neurologic injury will be enrolled as non-SCI spine trauma control participants.
Sponsor: AO Foundation, AO Spine
You may qualify if…
- ✓ Age ≥ 19 years
- ✓ Blunt (non-penetrating) traumatic SCI
- ✓ Baseline neurologic impairment deemed "complete" (AIS grade A) or "incomplete" (AIS grade B, C, or D) based on clinical history/examination and/or diagnostic imaging
- ✓ Bony spinal level involvement between C0 and L1, inclusive
- ✓ Ability to have initial blood sample drawn within 24 hours of injury
- ✓ Treated either surgically or non-surgically
- ✓ Ability to provide informed consent according to the IRB/EC defined and approved procedures
- ✓ Age ≥ 19 years
You may not qualify if…
- ✕ Penetrating SCI (eg, gunshot, stab)
- ✕ Previous SCI
- ✕ Isolated spinal injury below L1
- ✕ Isolated radiculopathy without fracture
- ✕ Isolated cauda equina injury
- ✕ Patients with known diagnosis of multiple sclerosis
- ✕ Preexisting thromboembolic disease or coagulopathy (disorders related to blood clotting), such as hemophilia or von Willebrand disease
- ✕ Patients who in the investigator's opinion will not be compliant with the study procedures and patients who have any other conditions/injuries that in the investigator's opinion would render the study procedures dangerous
Where it's recruiting
Wisconsin
Milwaukee
Source: ClinicalTrials.gov · NCT06839300 · last updated 2026-05-05