A Study to Improve Skeletal Muscle in Veterans With HIV
Eligible age
20–80 yrs
Accepts
Men
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The Department of Veterans Affairs is the largest single provider of medical care to people with HIV in the United States. The condition of excess lipid within and around muscle, termed myosteatosis, predisposes Veterans to physical function decline, frailty, disability, and cardiometabolic diseases such as diabetes and cardiovascular disease. In the investigators current Merit supported cohort, the investigators found that 36% of Veterans with treated HIV and obesity have "myosteatotic type obesity". Based on the investigators findings, the investigators have designed a multipronged integrated intervention that combines: 1) dietary replacement of saturated with unsaturated fats; 2) administration of L-carnitine and omega-3 fatty acid supplementation; and 3) targeted resistance exercise training.
Sponsor: VA Office of Research and Development
You may qualify if…
- ✓ Veteran
- ✓ HIV+
- ✓ antiretroviral therapy = integrase strand transfer inhibitor for at least 3 months
- ✓ HIV-1 RNA \<50 copies/ml
- ✓ age = 20 yrs
- ✓ BMI 28-50 kg/m2
You may not qualify if…
- ✕ unstable body weight (gain or loss \> 5% over past 3 months)
- ✕ diagnosed mitochondrial disorder
- ✕ diagnosed type 1 or type 2 diabetes
- ✕ use of metformin or other anti-diabetic agents for pre-diabetes
- ✕ hemoglobin A1c of \>6.5% at screening visit
- ✕ inflammatory conditions or chronic corticosteroid use
- ✕ stage 3 or greater kidney disease
- ✕ dietary or herbal supplements known to affect body weight, muscle mass, or immune function
Where it's recruiting
Nashville
Source: ClinicalTrials.gov · NCT06845046 · last updated 2026-06-26