RecruitingSepsis - to Reduce Mortality in the Intensive Care UnitTrauma Coagulopathy
ROTEM in Sepsis Trauma Outcome in Intensive Care
Eligible age
18+ yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
No
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About this study
This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced coagulopathy (TIC) in hospitalized patients with sepsis or trauma. Standard coagulation tests and ROTEM measurements will be collected and analyzed in relation to clinical outcomes.
Sponsor: Region Stockholm
You may qualify if…
- ✓ Trauma patients:
- ✓ Trauma alarm activated at hospital admission New Injury Severity Score (NISS) \> 15 Transfer to hospital within 7 days of trauma with NISS \> 15
- ✓ Sepsis patients:
- ✓ Meeting Sepsis-3 criteria Receipt of intravenous beta-lactam or aminoglycoside antibiotics within 48 hours of admission
- ✓ Control group:
- ✓ Patients undergoing elective surgery without expected coagulopathy
You may not qualify if…
- ✕ Trauma patients:
- ✕ Isolated chronic subdural hematoma No underlying traumatic event despite trauma alarm Age \<18 years
- ✕ Sepsis patients:
- ✕ Age \<18 years
- ✕ Control patients:
- ✕ Ongoing anticoagulant treatment Life-threatening illness (ASA IV-V) Age \<18 years
Source: ClinicalTrials.gov · NCT06891599 · last updated 2025-03-24