TMS for Cognitive Decline in Aging and Preclinical AD
Eligible age
40–99 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measured with behavioral tests, as well as by taking brain images with Magnetic Resonance Imaging (MRI). Participants will come in for one baseline visit followed by 10 days of daily rTMS study visits (Monday through Friday) and an evaluation visit. Then, there will be a 2-week break. After this break, they will return for another baseline visit, an additional 10 days of rTMS, and a final evaluation visit.
Sponsor: Massachusetts General Hospital
You may qualify if…
- ✓ 1. Between the ages of 40-99
- ✓ 2. Native English speakers
- ✓ 3. Willing and able to consent to the protocol and undergo imaging and neuropsychological testing at the specified time points
- ✓ 4. Cognitively normal older adults and individuals with preclinical Alzheimer's disease will be included.
You may not qualify if…
- ✕ 1. History of head trauma involving loss of consciousness or alteration in consciousness
- ✕ 2. Another major neurologic or psychiatric condition
- ✕ 3. Known presence of a structural brain lesion (e.g. tumor, cortical infarct)
- ✕ 4. Any contraindication to MRI, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
- ✕ 5. Longstanding premorbid history (i.e. longer than 10 years) of alcohol or substance abuse with continuous abuse up to and including the time that the symptoms leading to clinical presentation developed
- ✕ 6. Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol.
- ✕ 7. Unwilling to return for follow-up, undergo neuropsychological testing, TMS, and MR imaging
- ✕ 8. History of unprovoked seizures (i.e., seizures that occur in the absence of a clear provocation such as hyponatremia, hypoglycemia, etc.).
Where it's recruiting
Boston
Source: ClinicalTrials.gov · NCT06956300 · last updated 2026-02-20