The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
Eligible age
25–70 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The investigators recently demonstrated that blockade of Glucagon-Like Peptide-1's (GLP-1) receptor (GLP1R) results in changes in islet function without changes in circulating GLP-1. These effects are more pronounced in people with early type 2 diabetes (T2DM) in keeping with increased expression of PC-1/3 and GLP-1 that is observed in diabetic islets. However, its regulation is at present unknown. There is evidence that α-cell proglucagon processing is subject to paracrine regulation by the β-cell3. It is unclear if the effects of GLP1R agonism on islet GLP-1 differ in Type 1 diabetes (T1DM) compared to T2DM. This experiment will examine the effect of glycemic control ± a GLP1R agonist on islet GLP-1 in people with (T2DM) and without (T1DM) β-cells.
Sponsor: Mayo Clinic
You may qualify if…
- ✓ Type 1 or type 2 diabetes treated with insulin
You may not qualify if…
- ✕ 1. Age \< 25 or \> 70 years.
- ✕ 2. HbA1c \> 10.0%
- ✕ 3. For female subjects: positive pregnancy test at the time of enrollment or study
- ✕ 4. History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
- ✕ 5. Prior use of GLP-1 receptor agonists in the previous year.
- ✕ 6. Active systemic illness or malignancy.
- ✕ 7. Symptomatic macrovascular or microvascular disease.
Where it's recruiting
Rochester
Source: ClinicalTrials.gov · NCT06976619 · last updated 2025-10-14