RecruitingTwin to Twin Transfusion SyndromeTwin Anemia-Polycythemia Sequence
Evaluation of Laparotomy With Trans-Amniotic Suture Placement in TTTS Surgery
Eligible age
18+ yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
This is a randomized trial for patients that are diagnosed with Twin-Twin Transfusion Syndrome (TTTS) who are receiving a fetoscopic laser surgery to evaluate the effectiveness and safety of a laparotomy closure.
Sponsor: Children's Hospital Medical Center, Cincinnati
You may qualify if…
- ✓ Diagnosis of TTTS or Twin Anemia-Polycythemia Sequence (TAPS)
- ✓ Gestational age between 18 weeks and 23 weeks (18 0/7 to 22 6/7 weeks)
- ✓ Cervical length \>2.5 cm preoperatively
- ✓ Identification of a safe percutaneous surgical window by a provider experienced in fetoscopic surgery prior to entering the operating room
You may not qualify if…
- ✕ Higher order pregnancies, chromosomal or severe congenital anomalies, undergoing laser surgery for fetal growth restriction only, need for a second laser during pregnancy, failure to complete laser, PPROM prior to surgery. BMI\> 40 at the start of pregnancy, emergent case (i.e. surgery occurs \< 6 hours from presentation), significant fetal anomalies expected to drastically alter the risk of neonatal morbidity or mortality (i.e. anencephaly, cyanotic heart disease), or any significant maternal comorbidities as determined by physician i.e.: clotting disorders/blood disorders.
Where it's recruiting
Ohio
Cincinnati
Source: ClinicalTrials.gov · NCT06991400 · last updated 2025-05-28