RecruitingType 2 DiabetesHepatic Steatosis
Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis
Eligible age
25–55 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The overall aim of this study is to investigate the effects of exercise on the amount of glucose that is made by the liver in people with and without Type 2 diabetes (T2D) and hepatic steatosis (fatty liver).
Sponsor: AdventHealth Translational Research Institute
You may qualify if…
- ✓ 1. Provision of signed and dated informed consent form
- ✓ 2. Stated willingness to comply with all study procedures and availability for the duration of the study
- ✓ 3. Male or (pre-menopausal) female, aged 25-55 years
- ✓ 4. Body mass index (BMI) between 25 and 45 kg/m2
- ✓ 5. Sedentary (1 day or less per week of structured exercise)
- ✓ 6. Type 2 diabetes mellitus: HbA1c ≥7.5%
- ✓ 7. Liver fat ≥5.6% based on MRI
- ✓ 8. Weight stable (± 2 kg) for prior 3 months
You may not qualify if…
- ✕ 1. Exclusion criteria for individuals with T2D and elevated liver fat ≥5.6% Currently taking insulin, incretin mimetics, and/or thiazolidinediones
- ✕ 2. Any change in glucose-lowering medications within the previous three months.
- ✕ 3. Inability to stop any medications which interfere with glucose metabolism for visits 4 and 7.
- ✕ 4. Resting blood pressure ≥ 160/100 mm Hg
- ✕ 5. Triglycerides ≥ 500 mg/dL
- ✕ 6. Any renal, cardiac, liver, lung, or neurological disease that in the opinion of the principal investigator would compromise participant safety or the participants' ability to complete the exercise protocol
- ✕ 7. Any significant disease or unstable medical condition (i.e., coronary heart disease, chronic renal failure, chronic hepatic disease, severe pulmonary disease)
- ✕ 8. Presence of clinically significant abnormalities on electrocardiogram (ECG) that is a contra-indication to exercise testing
Where it's recruiting
Florida
Orlando
Source: ClinicalTrials.gov · NCT06993454 · last updated 2026-04-17