The Link Between Physical Activity and Brain Health in Healthy Adults
Eligible age
40–75 yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The goal of this observational study is to investigate the cross-sectional relationship between physical activity and brain health from a multiscale approach (neuropsychology, neuroimaging, peripheral biomarkers and genetics) in former athletes and sedentary individuals. The main question it aims to answer is: Do former athletes have better brain structure than sedentary people? Evaluating the differences in neurodegenerative processes between competitive training and sedentary and inactivity.
Sponsor: Technical University of Madrid
You may qualify if…
- ✓ Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity).
- ✓ Group B: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or IPAQ score\<600 MET min/week).
- ✓ In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.
- ✓ Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition
You may not qualify if…
- ✕ Medical conditions that have a high risk of associated cognitive symptoms.
- ✕ Severe head injury with loss of consciousness within the previous 5 years.
- ✕ Alcoholism (\>3 alcoholic drinks per day).
- ✕ Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.
- ✕ Hearing or visual impairment that would preclude testing
- ✕ History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).
- ✕ Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).
- ✕ Presence of severe systemic disease (e.g., cancer under treatment).
Source: ClinicalTrials.gov · NCT07025070 · last updated 2025-06-17