RecruitingGeneralized Anxiety Disorder (GAD)Anxiety Disorders
Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder
Eligible age
18–45 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This randomized, double-blind, placebo-controlled clinical trial investigates the use of Food and Drug Administration (FDA)-approved cannabidiol (EPIDIOLEX®) as an adjunct to cognitive behavioral therapy (CBT) in adults with generalized anxiety disorder (GAD). The study aims to evaluate whether cannabidiol-assisted CBT enhances emotion regulation via dorsomedial prefrontal cortex (dmPFC) activation and improves anxiety symptom outcomes compared to CBT with placebo.
Sponsor: Wayne State University
You may qualify if…
- ✓ Right-handed
- ✓ Age 18-45 years at enrollment
- ✓ Able to consent to the study
- ✓ Agree to adhere to lifestyle considerations throughout study duration
- ✓ Generally medically and neurologically healthy, including no evidence of intellectual disability or serious cognitive impairment
- ✓ Have a current generalized anxiety disorder (GAD) diagnosis according to the The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria and/or total scores ≥ 8 on the 7-Item Generalized Anxiety Disorders Scale (GAD-7)
You may not qualify if…
- ✕ Clinically significant medical or neurologic condition or neurocognitive dysfunction that would affect function and/or task performance and/or interfere with the study protocol
- ✕ Any current (or within past 2 months) medical condition requiring medication that would interact with cannabidiol or interfere with the study protocol
- ✕ Risk of harm to self or others that requires immediate intervention
- ✕ Presence of contraindications, current or past allergic or adverse reaction, or known sensitivity to cannabinoid-like substances or components of EPIDIOLEX®
- ✕ Positive drug screen or alcohol breathalyzer
- ✕ Unwilling/unable to sign informed consent document
- ✕ Currently pregnant (positive pregnancy test), planning pregnancy, or lactating (women),
- ✕ Under 18 or over 45 years of age
Where it's recruiting
Michigan
Detroit
Source: ClinicalTrials.gov · NCT07123467 · last updated 2026-03-09