RecruitingMusculoskeletal AbnormalitiesObesitySarcopenic Obesity
GLP-1R Actions on Muscle and the Skeleton
Eligible age
18–50 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
The GRAMS study objectives are to assess the musculoskeletal changes that occur after weight loss using GLP-1 based therapy. A lifestyle intervention with diet and exercise is included to assess any mitigating effects are provided, versus a control group with regular exercise and diet.
Sponsor: Pennington Biomedical Research Center
You may qualify if…
- ✓ Subjects will have a BMI between 30kg/m2
- ✓ 40kg/m2 (inclusive)
- ✓ Be between 18 and 50 years of age (inclusive).
- ✓ Non-Hispanic Black males and females will be enrolled at PBRC.
- ✓ Rural males and females will be enrolled at MaineHealth.
- ✓ Female subjects will be premenopausal.
- ✓ Females have had their last menstrual period less than 60 days before screening.
- ✓ Females have the absence of menopausal-associated vasomotor symptoms.
You may not qualify if…
- ✕ \- Males and females over the age of 50 years of age
- ✕ Menopausal females.
- ✕ Subjects on systemic corticosteroids or other agents known to increase loss of muscle and bone mass.
- ✕ Subjects who are on medications that increase or decrease weight status.
- ✕ Subjects having contraindications to tirzepatide in the package insert.
- ✕ Subjects with a history of malignancy other than non-melanoma skin cancer
- ✕ Subjects with known osteoporosis or are on osteoporosis therapies (gonadal hormones or hormone antagonists).
- ✕ Subjects with uncontrolled thyroid or parathyroid disease that may influence the study results.
Where it's recruiting
Louisiana
Baton Rouge
Source: ClinicalTrials.gov · NCT07154719 · last updated 2026-05-29