Characterizing the Human Airway Immune Response to FluMist Vaccination
Eligible age
18–40 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The goal of this clinical trial is to measure the immune response in the blood, nose, and lungs after participants receive either the FDA-approved inactivated influenza vaccine or the FDA-approved intranasal FluMist vaccine. The study will evaluate immune responses in groups of healthy, non-pregnant, volunteers between the ages of 18 and 40. The main purpose of the study is to measure the change in influenza vaccine-specific antibodies in the lower lungs and nose between vaccination and 14 days after participants receive the vaccine. All participants will be randomized to receive one of the two seasonal flu vaccines and will have blood and back of the nose swabs collected throughout the study. Some study participants will choose to undergo optional bronchoscopy procedures and will be included in the part of the study looking at lower lung immune responses.
Sponsor: Washington University School of Medicine
You may qualify if…
- ✓ Healthy adults aged 18-40 years
- ✓ Able to understand and give written informed consent
- ✓ In stable health, as determined by medical history and targeted physical exam related to the history
You may not qualify if…
- ✕ Prisoners
- ✕ Anyone unable to provide full written informed consent
- ✕ Pregnant women and nursing mothers or women who are planning to become pregnant during the study interval
- ✕ Female subjects who are sexually active with male partners who are not actively on hormonal contraception or who do not have an IUD in place
- ✕ Vaccination with a seasonal influenza vaccine or documented infection with seasonal influenza in the past 9 months
- ✕ Receipt of any vaccine in the 28 days prior to the pre-vaccination study visit or planned receipt of any non-study vaccine before completion of study day 28 visit
- ✕ Current smokers
- ✕ BMI \> 40
Where it's recruiting
St Louis
Source: ClinicalTrials.gov · NCT07177417 · last updated 2025-09-17