RecruitingAlcohol Use Disorder
Hepatic Lipid Metabolism-Alcohol Use Disorder
Eligible age
18–100 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Patients with hepatic steatosis due to alcohol will be offered liver biopsies when they enter a detoxification program. The first biopsy will occur in the first week of admission and the second in the fourth week when the steatosis has resolved. The hepatic transcriptome will be compared,
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
You may not qualify if…
- ✕ An individual who meets any of the following criteria will be excluded from participation in this study:
- ✕ Pregnancy
- ✕ Existing diagnosis of hyperlipidemia or essential hypertension
- ✕ Hemoglobin A1c \>= 6.5%
- ✕ Waist to hip ratio: \>=0.90 in males, \>=0.85 in females
- ✕ Existing use of cholesterol lowering medications including statins, fibrates, or other similar medications used for the purposes of treating hyperlipidemia.
- ✕ Those with evidence of severe alcoholic hepatitis with a Maddrey s Discriminant Function \> 32
- ✕ Those with other chronic liver diseases including chronic hepatitis B (positive hepatitis B surface Ag on admission), hepatitis C (positive hepatitis C RNA), or autoimmune hepatitis (clinical diagnosis based on high titer of positive ANA and or anti smooth muscle Ab and a history of autoimmune disease)
Where it's recruiting
Maryland
Bethesda
Source: ClinicalTrials.gov · NCT07191561 · last updated 2026-06-15