RecruitingKRAS Mutant Solid Tumors
TLN-372 in Advanced KRAS Mutant Solid Tumors
Eligible age
18+ yrs
Accepts
All genders
Locations
6 states
Healthy volunteers
No
See if you qualify for this study
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About this study
The primary purpose of this study is to evaluate the safety, pharmacokinetics, and anti-tumor activity of TLN-372 as a single agent and in combination with other anti-tumor agents, in patients with advanced KRAS mutant solid tumors
Sponsor: Treeline Biosciences, Inc.
You may qualify if…
- ✓ 1. Patients must have measurable disease at study entry.
- ✓ 2. Patients must have locally advanced or metastatic KRAS mutant solid tumors.
- ✓ 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- ✓ 4. Adequate organ function.
You may not qualify if…
- ✕ 1. Patients must not have active brain metastases.
- ✕ 2. Patients must not have current or past history of central nervous system (CNS) involvement.
- ✕ 3. Patients must not have major surgery or severe trauma within 4 weeks prior to the start of the study.
- ✕ 4. Patients must not have any condition, including significant acute or chronic medical illness, active or uncontrolled infection, or the presence of laboratory abnormalities, that places patients at unacceptable risk of participating in this study.
- ✕ 5. Patients must not have clinically significant cardiovascular disease.
- ✕ 6. Pregnant or lactating.
- ✕ 7. Conditions that could affect drug absorption.
Where it's recruiting
Source: ClinicalTrials.gov · NCT07204340 · last updated 2026-07-28