RecruitingPost Operative PainSpinal Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
Eligible age
18–72 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and safety of postoperative oral methadone in patients undergoing spine surgery and collect preliminary data to inform a larger clinical trial that will test the opioid-sparing effects of methadone at 3 months after spine surgery.
Sponsor: The Cleveland Clinic
You may qualify if…
- ✓ Adult ≥ 18 years of age
- ✓ Scheduled for multilevel lumbar and/or thoracic spine fusion (primary or revision)
You may not qualify if…
- ✕ \<18 or \>72 Years of age
- ✕ Body Mass Index \>40
- ✕ Known allergy to methadone
- ✕ Pregnant females
- ✕ Non-English-speaking patients
Where it's recruiting
Ohio
Cleveland
Source: ClinicalTrials.gov · NCT07222072 · last updated 2025-12-17